Therefore, there is evidence that minerals, such as chromium and zinc, which are contained in the Combo treatment, are effective in improving glucose tolerance and reducing insulin resistance in beef cattle [24,75,76,77], increasing insulin binding and the number of insulin receptors and enzymes, and promoting insulin sensitivity through β-cells and facilitating its internalization [78,79], thus positively regulating gluconeogenesis [24]. Here, INSR is linked to Insulin resistance.