One dog was initially administered with 2 mg Chlorambucil biweekly (10.8 mg × m2 weekly; 1.5 mg × m2 daily) and 2.7 mg/kg Toceranib triweekly and then experienced G1 neutropenia, G1 anorexia, and G2 ALT elevation. This evidence concerns the gene GPT and Decreased total neutrophil count.