Other major ribosomopathies related to the hub genes obtained in this study mainly include familial encephalopathy with neuroserpin inclusion bodies (FENIB), associated with RPS3A; brachycephaly, trichomegaly, and developmental delay and autism spectrum disorder, associated with RPS23; and epilepsy, idiopathic generalized 14 and coenzyme Q10 deficiency, associated with RPL28 [47]. This evidence concerns the gene RPS3A and Global developmental delay.