SPRED2 and cyclic hematopoiesis: Besides the common CH-associated mutations, they identified 17 additional mutated genes, namely, ZBTB33, ZNF318, ZNF234, SPRED2, SH2B3, SRCAP, SIK3, SRSF1, CHEK2, CCDC115, CCL22, BAX, YLPM1, MYD88, MTA2, MAGEC3, and IGLL5. Clones with these mutations expanded in variant frequencies and clone sizes in an age-dependent manner, comparable to classical CH drivers.