According to the WHO and ICC, the diagnostic criteria for differentiating CNL are peripheral blood white blood cell count and no dysgranulopoiesis (the WHO suggests ≥25 × 109/L, but ICC ≥13 × 109/L., normal neutrophil granulocytes maturation with hypercellular bone marrow, the presence of the CSF3R T618I mutation or another activating CSF3R mutation, and the absence of the Philadelphia chromosome [5,6]. The gene discussed is CSF3R; the disease is intrahepatic cholangiocarcinoma.