An interesting study revealed that adiponectin deficiency significantly reduces pancreatic tumorigenesis in vivo, while adiponectin’s interaction with adipoR1 prevents apoptosis in both human and mouse pancreatic cancer cells, a mechanism central to which is the activation of the AMP-activated protein kinase (AMPK) and SIRT1 axis [83]. This evidence concerns the gene SIRT1 and pancreatic neoplasm.