Another important function of the ECM is to serve as a reservoir for regulatory factors such as Vascular Growth Factors (VEGFs), Fibroblast Growth Factors (FGFs), Transforming Growth Factors (TGFs), Epidermal Growth Factor (EGF), Platelet-Derived Growth Factors (PDGFs), and others, which are all involved in tumor development [17]. This evidence concerns the gene EGF and neoplasm.