It belongs to the microphthalmia family of evolutionarily conserved members in the vertebrates, also including TFEC, TFE3, and MITF (microphthalmia-associated transcription factor) [56], whereby the latter one has recently been shown to play a key role in TPC2/Rab7a-driven effects in melanoma cells [30]. This evidence concerns the gene TPCN2 and melanoma.