MCOLN1 and cancer: Thus, activation of TRPML1 was found to lead to cancer cell death by impairing mitochondrial function and might, therefore, be beneficial in cancer therapy, while in the same cells, TRPML1 loss-of-function leads to mitophagy defects, which, despite impairing mitochondrial function, do not induce cell death but instead result in a reduced rate of proliferation [15,41,43,44,45,46].