RAB7A and neoplasm: These findings suggested that Rab7a is an “effector” of TPC2 but not vice versa (with “effector” being defined here as an upstream molecule (Rab7a) interacting with a downstream target (TPC2) to increase its activity) and that effects of Rab7a on proliferation, migration, and invasion of tumor cells are mediated predominantly by TPC2.