Kasitinon et al. (2019) demonstrated that the loss of TRPML1 in melanoma impairs proliferation in vitro and reduces melanoma tumor growth in vivo without affecting normal melanocytes via upregulation of MAPK and mTORC1 signaling, overcoming proteotoxic stress [15,16,41,42,43]. Here, MCOLN1 is linked to neoplasm.