TP53 and Familial adenomatous polyposis: While ACCs can be associated with rare genetic syndromes, such as Beckwith–Wiedemann syndrome (due to alterations on chromosome 11p15.5), Li–Fraumeni syndrome (related to TP53 mutations), multiple endocrine neoplasia (MEN) type 1, and familial adenomatous polyposis (FAP), most cases are sporadic [1,2,3].