For example, ADAMTS-1, -4, -5, -8, -9, -15, and -20 predominantly exhibit proteoglycanase activity, with VCAN and ACAN as their main substrates in various tumor types (pancreatic, hepatocellular, brain, melanoma, prostate, and breast), as well as in extracellular matrix remodeling, proliferation, and morphogenesis in embryonic tissue [11,17]. Here, VCAN is linked to neoplasm.