Taken together, these studies reaffirm our bioinformatics-based analysis and suggest that these extracellular matrix genes (CDH3, COL11A1, COL1A1, COL17A1, KRT19, ITGA2, LAMC2, and SULF1) are highly associated with PDAC tumor carcinogenesis and peritoneal metastasis. This evidence concerns the gene CDH3 and neoplasm.