HMGB3 and non-small cell lung carcinoma: Oncogenes like TIPE and high mobility group protein 3 (HMGB3) also influence this pathway; TIPE promotes NSCLC cell proliferation by downregulating Wnt/β-catenin signaling, while HMGB3 is linked to poor prognosis due to its role in enhancing Wnt signaling activity [54,55].