VEGFC and neoplasm: Moreover, tumor cell-derived EVs have been shown to stimulate lymphangiogenesis through the transfer of various RNA species such as miR-1246 or miR-221-3p [81,82] and the lncRNA LNMAT2 [83], RNA-binding proteins stabilizing PROX-1 expression in LECs [84], and direct association of EVs with VEGF-C protein [85].