CD274 and gastric cancer: There are several ongoing studies assessing multimodal strategies using a combination of chemotherapy and ICIs in MSI-H tumors versus ICIs only (EA2212), as well as trimodal perioperative strategies with a combination of chemotherapy, ICIs, and post-surgery radiotherapy in patients with MSI-H, EBV(+), or PDL1 CPS ≥ 1 gastric cancers (NCT03257163) [40,45].