The impact of primary tumor resection on survival is affected by age, race, cohabitation status, income, tumor size, grade and histology, ER, PR or Her2 status, expression of Ki67 and CA15, alkaline phosphatase, lymphovascular invasion, lymph node status, metastasis to brain, liver, and lung, and chemotherapy [27,29,30]. The gene discussed is ESR1; the disease is neoplasm.