Instead, monoallelic PALB2 PVs can be found in 0.4% to 3.9% of breast cancer patients and have been linked to a 41–60% risk of breast cancer, a 3–5% risk of ovarian cancer, and 2–5% risk of pancreatic cancer [1,3,7,18]. The gene discussed is PALB2; the disease is breast carcinoma.