The four molecular subgroups are (1) ultramutated tumors characterized by POLE hotspot mutations, with excellent prognosis; (2) hypermutated tumors characterized by mismatch repair deficiency (MMRd), resulting in microsatellite instability (MSI), with good/intermediate prognosis; (3) tumors with no specific molecular profile (NSMP) or copy number low (p53 wild-type), with intermediate prognosis; (4) copy number-high (CNH) tumors characterized by TP53 mutations (p53 abn), with poor prognosis [7]. This evidence concerns the gene TP53 and mismatch repair cancer syndrome 1.