MED1 and breast cancer: Moreover, there are a number of intrinsic and extrinsic factors have also been reported to be involved in anti-estrogen treatment resistance of human breast cancer, it will be important to further study the biological impact of miR-205/MED1 axis, both within tumor cells including tumor stem cells, and in the interaction and communication of tumor cells with the tumor microenvironment (e.g., exosomes, adipose cells, MSCs, immune cells) in the future [66,67,68,69].