Therefore, the aim of the present study was to determine the diagnostic utility of collagenases (MMP-1, MMP-8 and MMP-13), a group of enzymes belonging to matrix metalloproteinases, in the biochemical diagnosis of ovarian carcinoma in comparison with patients with benign ovarian lesions (Serous cystadenomas) and healthy women, compared with the routinely used HE4 and CA125 markers and the ROMA. This evidence concerns the gene MMP13 and serous cystadenoma.