The aim of this study was to determine the diagnostic utility of collagenase group metalloproteinases—MMP-1, MMP-8 and MMP-13—in patients with OC, compared to women with benign ovarian lesions (Serous cystadenomas) and healthy subjects in comparison with classical markers (CA125 and HE4) and the ROMA. The gene discussed is MMP1; the disease is serous cystadenoma.