In adult ACC, IGF2 overexpression linked to 11p15.5 abnormalities (e.g., loss of heterozygosity or UPD) is a common marker distinguishing ACC from ACA [60,61]; however, in pediatric ACTs, UPD(11)pat and IGF2 overexpression are found in both ACA and ACC [62,63]. This evidence concerns the gene IGF2 and adrenal cortex carcinoma.