Five patients underwent molecular testing on tumor DNA: one exhibited a complex abnormal karyotype [21], one carried marked IC2-LoM [14], one showed a high level of genome-wide UPDpat [22], one exhibited LOH of chromosome 17p13 [24], and one carried a somatic pathogenic variant in the CTNNB1 gene [13]. Here, CTNNB1 is linked to neoplasm.