The mutational T-ALL landscape also includes CDKN2AB, TLX1, NKX1, and KMT2A deletions; ABL1 rearrangements; and IL7R, JAK3, JAK1, WT1, FBXW7 [99], PTEN, RPL10 [155], or NOTCH (9q34.3) mutations [161,162]. Here, KMT2A is linked to acute lymphoblastic leukemia.