In recent years, the genomic analysis of ALL in clinical practice has been performed using standard techniques that allow for the detection of the most frequent alterations defining molecular subtypes, such as ploidy alterations (hyperdiploidy or hypodiploidy), intrachromosomal amplifications, or gene fusions (BCR::ABL1, ETV6::RUNX1, KMT2Ar) (Figure 1). Here, ETV6 is linked to acute lymphoblastic leukemia.