Our recent studies implicated GR, a nuclear steroid receptor linked to PCa resistance to both anti-androgen therapy and taxane chemotherapy [142,143,144,145], in the transcriptional activation of LEDGF/p75 as well as the nuclear translocation of its IBD interactor JPO2 in chemoresistant PCa cells [49,50,146]. Here, NR3C1 is linked to posterior cortical atrophy.