Elevated expression of LEDGF/p75 in LECs and cancer cells also upregulates the expression of genes associated with oxidative stress responses including alpha B crystallin (CRYAB/HSPB5), involucrin (IVL), cytoglobin (CYGB), antioxidant protein 2/peroxiredoxin 6 (AOP2/PRDX6), alcohol dehydrogenases (ADH), aldehyde dehydrogenases (ALDH), and the oxidoreductase and glucose-regulated protein GRP58/ERp57/PDIA3 [18,25,26,29,31,34,35]. The gene discussed is CYGB; the disease is cancer.