To assess the role of LEDGF/p75 in cancer chemoresistance, they ectopically overexpressed this protein in MCF7 BCa cells and other cancer cell lines and noticed enhanced lysosomal stability and protection against anti-tumor drugs that induced lysosomal membrane permeabilization (LMP) and DNA damage such as siramesine, BAMLET (a complex of alpha lactalbumin and oleic acid), etoposide and doxorubicin [41,150]. The gene discussed is PSIP1; the disease is cancer.