Given that LEDGF/p75 knockout in mice has been associated with defects in hematopoiesis, suppression of T-ALL initiation, and developmental craniofacial and skeletal abnormalities [69,134,136], and that this protein plays an important role in protecting ocular cells from environmental stressors [23,24,25,26,27,28,29,30,31,32,33], it would be crucial to ascertain in pre-clinical animal models of cancer if its pharmacological inhibition causes serious side effects. The gene discussed is PSIP1; the disease is acute lymphoblastic leukemia.