PSIP1 and leukemia: These investigators proposed that the chemoresistance-promoting functions of LEDGF/p75 in leukemia are possibly driven via a mechanism involving regulation by this protein of its IBD-interacting partner MED1 and the bromodomain protein BRD4, resulting in stable and active nuclear super-enhancers, leading to the activation of gene pathways associated with cell cycle checkpoints, cell survival, and stem cell renewal.