PSIP1 and posterior cortical atrophy: Consistent with this, our group observed that enforced overexpression of LEDGF/p75 in PCa cells protected against docetaxel-induced lysosomal cell death and oxidative-stress induced necrosis, but not against classical apoptosis inducers such as tumor necrosis factor related apoptosis inducing ligand (TRAIL) or staurosporine, suggesting selectivity in its pro-survival activity [46].