We observed that like LEDGF/p75, HRP-2 contributes to the survival, clonogenicity, and tumorsphere formation capacity of docetaxel-resistant PCa cells [50], consistent with the emerging role of HRP-2 as an oncoprotein that influences epigenetic transcriptional regulation and anti-tumor drug responses in cancer cells [93,94,116,117]. This evidence concerns the gene HDGFL2 and neoplasm.