For instance, a recent study by Demoen et al. [136] showed that knockout of the PSIP1 gene encoding LEDGF/p75 in spontaneous mouse models of T cell acute lymphoblastic leukemia (T-ALL) accelerated T-ALL initiation in mice, which correlated with altered H3K27me3 signaling. The gene discussed is PSIP1; the disease is acute lymphoblastic leukemia.