A recent pan-cancer bioinformatics study by Zhang et al. [51] revealed that LEDGF/p75 transcript and protein expression are differentially regulated in multiple primary cancers, with increased expression in some tumors (e.g., head and neck squamous cell carcinoma, [HNSC], and thymoma) and downregulation in others (e.g., BCa and PCa), and some cancers showing opposite expression of transcript and protein levels in the same tumor type. This evidence concerns the gene PSIP1 and posterior cortical atrophy.