PSIP1 and renal carcinoma: Kanu et al. [160] provided evidence that loss-of-function of SETD2 in renal carcinoma (RCC) is associated with reduced chromatin binding of H3K36me3 and LEDGF/p75, leading to increased DNA damage due to the failure of LEDGF/p75 and RAD51 to load into DSB sites.