Cohen et al. [37] observed that ectopic LEDGF/p75 expression mediated the transcriptional activation of VEGF-C in glioma and non-small cell lung carcinoma cells in vitro, and stimulated VEGF-C expression and augmented angiogenesis and lymphangiogenesis in subcutaneous mouse tumor xenografts. The gene discussed is PSIP1; the disease is central nervous system cancer.