An unbiased proteomic screening analysis of lenvatinib-sensitive parental and lenvatinib-resistant HCC cells unraveled marked upregulation of methyltransferase-like protein-1 (METTL1) and WD repeat domain 4 protein (WDR4), which are components of the tRNA N7-methylguanosine (m7G) methyltransferase complex [64]. The gene discussed is METTL1; the disease is hepatocellular carcinoma.