In HCC patients, ZFAS1 levels correlated with levels of stemness and EMT-regulating genes, known to be associated with sorafenib resistance in HuH-7 and Hep3B cells, and siRNA-mediated ZFAS1 knockdown made sorafenib-resistant cells sensitive [139]. The gene discussed is ZFAS1; the disease is hepatocellular carcinoma.