Additionally, the protective effect of both BDNF and GDNF observed in this work seems to be mediated by the activation of CK2 in U-87 cells and reversed by inhibition of its signaling with a specific CK2 inhibitor that decreased the survival of neurotrophins, suggesting that the blocking of GBM progression occurred by CX-4945 required CK2 inhibition of phosphorylation mediated by neurotrophins activation. The gene discussed is GDNF; the disease is glioblastoma.