The GBM microenvironment produces several pro-inflammatory cytokines and mediators, including interleukin-1β (IL-1β) and interleukin-8 (IL-18), that play key roles in the GBM through activation of downstream targets such as protein kinases signaling pathways, Janus kinase/signal transducer, and activator of transcription 3 (JAK/STAT3) [2]. The gene discussed is STAT3; the disease is glioblastoma.