To confirm these observations, we evaluated the oxidative stress in U-87 cells, a cell line usually utilized as an experimental standard for founding novel therapeutic strategies for GBM, and we found that CX-4945 exerts its pharmacological effect by downregulating antioxidant enzymes HO-1 and MnSOD; that result aligns with previous findings indicating that both play a significant role in controlling cell proliferation and cell cycle progression. This evidence concerns the gene SOD2 and glioblastoma.