During GBM progression, uncontrolled proliferation of cells leads to the instability of the tumor microenvironment with tumor cells also invading surrounding tissue up to the BBB, where results of said invasion are characterized by loss of integrity and breakdown of tight junctions of the endothelium, contributing to the extravasation of the tumoral cells expressing cytokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and growth factors [3]. Here, TNF is linked to neoplasm.