MTOR and neoplasm: Using cell cultures such as activation of RAGE by MG-AGEs has been well established in many types of cancers, showing that RAGE activation inhibits apoptosis [37], induces inflammation and neo-angiogenesis via the vascular endothelial growth factor (VEGF) [26], and finally promotes tumor growth and metastasis via pathways such as AP-1, NF-kB, PI3K and mToR [26].