We know that Glo-1 is over-expressed in many types of cancers [39,40], possibly as a consequence of the higher accumulation of MG in cancer cells [41], while Glo-2 expression might be decreased [42,43,44], meaning that the defect in MG detoxification may cause a saturation of the intracellular accumulation of MG, and consequently a release of free MG in the extracellular compartment. The gene discussed is HAGH; the disease is cancer.