BRCA1 and breast cancer: Likewise, while PRC2 is upregulated in BRCA1/2 PV hereditary breast cancer [10], the specificity of its association with lncRNAs remains elusive due to their diverse derivations [89], although various lncRNAs such as HOX antisense intergenic RNA (HOTAIR) and promotor of CDKN1A antisense DNA damage-activated RNA (PANDAR) have shown to play a role in breast cancer tumourigenesis through various mechanisms [93].