BRCA1 and breast cancer: Moreover, the suppression of pellino E3 ubiquitin protein ligase 1 (PELI-1), a destabiliser of the LSD-1/NuRD complex, which results in higher recruitment of LSD-1/NuRD complexes, has been shown to improve the prognosis of breast cancer as well as improve the efficacy of other therapeutics such as JQ1 in the treatment of both BRCA1 PV-associated and non-BRCA breast cancer [123].