CAFs were also able to transform into metastasis-associated fibroblasts (MAFs) and increase their expression of EMT markers such as Ezrin, Radixin Moesin and CCL5 (Figure 1), which are important for tumour cell mobility, to further induce metastatic changes in breast cancer cells and augment tumour proliferation, migration, and invasion (Table 1) [27]. This evidence concerns the gene CCL5 and neoplasm.