It has been shown that VEGF and HIF are more highly expressed in BRCA1/2 PVs than sporadic breast cancers [30] (Figure 1), and this has been attributed to the fact that BRCA1 can bind to the VEGF gene promoter, inhibiting its transcription and thus reducing VEGF secretion [31] (Table 1). This evidence concerns the gene BRCA1 and breast cancer.