APRT and cancer: Furthermore, the MRPL23 activity was intertwined with the signaling network, including genes that encode adenine phosphoribosyltransferase (APRT), which catalyzes the formation of AMP; mitochondrial protein MPRS15, which builds the 28S subunit protein; and 40S ribosomal protein S15 (PRS15), whose mutations repress RNA translation in cancers [21,22].