The HCC cell-derived exosomes exerted their functions by increasing the level of proteins related to sorafenib resistance, protecting tumor cells from sorafenib-induced apoptosis, activating the HGF/c Met/Akt pathway in vitro, and targeting the HGF/c-Met/Akt pathway, which may help improve treatment efficacy in liver cancer [75,76]. This evidence concerns the gene HGF and hepatocellular carcinoma.