EGFR’s tyrosine kinase activity inhibition observed with erlotinib and short hairpin RNA (shRNA) recovered the response of three SR HCC cell lines with the help of sorafenib, which suggests the crucial roles of EGFR tyrosine kinase and KLF4 in the induction of sorafenib resistance [36,37,38]. Here, EGFR is linked to hepatocellular carcinoma.