It is noteworthy that a functionally analogous autonomously acquired PIEZO2 channelopathy is proposed in DOMS and amyotrophic lateral sclerosis as well due to the dissociation of the auxiliary connection of the inhibitor protein ligands of PIEZO2, like MyoD [7] or TMEM120A [34]. The gene discussed is PIEZO2; the disease is amyotrophic lateral sclerosis.