Nineteen adenomas showed hormonal secretion: 11 secreted growth hormone (GH), 5 secreted adrenocorticotropic hormone (ACTH), 1 secreted both GH and prolactin (PRL), 1 secreted thyroid stimulating hormone (TSH) and 1 secreted follicle stimulating hormone (FSH). This evidence concerns the gene BRD2 and adenoma.