Adding NT-proBNP to this model showed that NT-proBNP was related to TropI levels (p < 0.001), but the estimate for SIS was only changed to a minor degree (now OR 1.12, 95%CI 1.08–1.15, p < 0.0001), suggesting that a failing heart is not driving the association between SIS and TropI. Here, NPPB is linked to benign neoplasm.