To investigate cellular death in the B16F10 mouse melanoma cell model and its correlation with the mechanism of RIPK1 downregulation rather than kinase inhibition, we employed various tool molecules, including LD4172, T2I, TNFα, Smac mimetic LCL161, and the pan-caspase inhibitor Z-VAD-FMK. This evidence concerns the gene RIPK1 and melanoma.