EGFR and cancer: In previous studies, there are two main hypotheses to explain the generation of concomitant mutations: (1) tumor heterogeneity, different tumor cells carry different tumor‐driver genes, and tumors may consist of two or more than two types of cancer cells, which carrying EGFR mutations or ALK fusion mutations; (2) the same tumor cell carry two or more tumor‐driver genes, and tumors consist of one type of cancer cells, which carrying both EGFR mutations and ALK fusion mutations.