A recent study by Edinet al. examined oxylipins in a mouse model of COVID with human angiotensin-convertingenzyme 2 (ACE2) expression.768 The studyinvestigated the effect of sEH inhibition upon the host response toinfection, focusing on the ensuring eicosanoid and cytokine storms.While circulatory levels of the DiHOMEs increased with infection anddecreased with sEH inhibitor treatment, there was no overall effecton morbidity or mortality. Here, EPHX2 is linked to infection.