Swardfager and co-workers were ableto correlate the ratios between 9,10-DiHOME and 9(10)-EpOME as wellas between 12,13-DiHOME and 12(13)-EpOME (an index of sEH activity)with white matter hyperintensities (WMH) and proposed this value asa biomarker for vascular cognitive impairment in patients with WMH.730 The increased diols and reduced epoxides wererelated to increased sEH activity, which was reflected in increasedlevels of sEH-derived oxylipins in serum, implicating CYP/sEH-dependentmetabolism in the etiology of WMH by injury to the periventricularsubcortical white matter. Here, EPHX2 is linked to Hyperintensity of cerebral white matter on MRI.