YME1L1 and acute kidney injury: Previous studies have indicated that YME1L1, an i‐AAA protease (ATPases associated with diverse cellular activities) with its protease domain anchored in the inner membrane, drives mitochondrial proteolytic rewiring and mitochondrial biogenesis mainly through degrading mitochondrial protein translocases in response to hypoxia or amino acid starvation.[6, 19] In this study, we observed that YME1L1 expression was reduced in cisplatin‐induced HK2 cells and AKI mice, and its restoration significantly ameliorated mitochondrial structural damage in vitro and in vivo.