m6A modification, a prevalent RNA modification in eukaryotic mRNA, is crucial for gene expression regulation.[12, 35] For example, in sepsis‐associated lung injury, METTL3‐mediated m6A modification enhanced the stability of ACSL4 mRNA, thereby promoting mitochondrial‐associated ferroptosis.[36] However, the role of METTL3 in renal mitochondria, particularly in mitochondria‐rich RTECs, has not been identified. Here, ACSL4 is linked to Sepsis.