YME1L1 and Disorder of lipid metabolism: As reported, mitochondrial damage is an early event in AKI, usually within several hours following AKI onset, before the occurrence of lipid metabolic disorders.[5, 31] This study indicated that the expression of SREBP1c significantly increased as early as 6 h after cisplatin treatment, accompanied by the suppression of YME1L1 transcription.