To further explore the expression and potential roles of YME1L1 in AKI, we constructed three AKI mouse models,[9] and found that YME1L1 expression was markedly inhibited at both transcriptional and translational levels in the kidney tissues of AKI mice induced by cisplatin, IRI, and folic acid (FA), compared with control mice (Figure 1h,i; Figure S2a–o, Supporting Information). This evidence concerns the gene YME1L1 and acute kidney injury.