Normally, SREBP1c, part of the SREBP family, is embedded in the endoplasmic reticulum as hairpins.[22] Under high glucose‐induced diabetes,[23] obesity‐associated nephropathy,[24] and other tissue‐injury stimuli,[22] SREBP1c undergoes proteolytic cleavage to produce a mature protein that enters the nucleus and modulates the transcription of target genes by binding to their sterol regulatory elements (SREs).[25] Here, we identified YME1L1 as a novel target gene of SREBP1c, which represses its expression by directly binding to the promoter region (‐214 to ‐205, 5′‐ATCGCGCCAC‐3′). This evidence concerns the gene SREBF1 and obesity disorder.