Numerous studies have explored the beneficial effects of miR‐16‐5p on cancer therapy, burn wound healing, and the inhibition of neutrophil extracellular trap formation and so on.[36, 37, 38] In the present study, it was elucidated that miR‐16‐5p alleviated hepatic IRI through binding to the 3′UTR region of SLC39A14 mRNA, which has already identified as a key pro‐ferroptosis target above. Here, SLC39A14 is linked to cancer.