KEAP1 and injury: For instance, sitagliptin can activate the p62–Keap1–Nrf2 signaling pathway to alleviate oxidative stress and excessive autophagy in acute lung injury, a mechanism that may also apply to OA improvement.[35] Furthermore, through a series of gain‐of‐function experiments, we demonstrated that DPP4 induces excessive mitochondrial fission, leading to oxidative stress and cellular senescence in chondrocytes, independent of its enzymatic activity.