A common insertion variant exhibits cis‐regulation potential for the m6A eraser ALKBH5, which demethylates FBXL5 mRNA, leading to reduction in reactive oxygen species levels, inhibition of PI3K/AKT and NF‐kB pathways, and consequent suppression of NSCLC cells. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.