PLCE1 and colorectal cancer: For example, previous studies implied that genetic variants at 16p13 interact remotely with the promoter of lncRNA GCLET, conferring the risk of gastric cancer.[30] Similarly, risk loci for colorectal cancer[31] and esophageal squamous cell carcinoma,[32] reportedly regulate the expression CATSPERE and PLCE1, through long‐range interactions with their promoters and by altering TF binding.