Interestingly, in the presence of ALKBH5 H204A mutation or FBXL5 synonymous mutation at the potential m6A sites, FBXL5 was unable to be upregulated by ALKBH5, suggesting the ALKBH5 protein and FBXL5 m6A sites were both responsible for m6A modification in NSCLC cells (Figure 6M). Here, ALKBH5 is linked to non-small cell lung carcinoma.