To further clarify the role of SHep‐EVs in macrophages, we co‐treated macrophages with IFN‐γ (10 ng mL−1) + LPS (100 ng mL−1) for 24 h to simulate the inflammatory state of macrophages in the context of atherosclerosis.[39] (Model group), and simultaneously treated these cells with different concentrations of SHep‐EVs (SHep‐EV group). Here, IFNG is linked to atherosclerosis.