APOE and atherosclerosis: Calcification is a feature of atherosclerosis associated with adverse cardiovascular events.[30] To clarify whether SHep‐EVs affect atherosclerotic vascular calcification (intimal calcification), a model of vascular intimal calcification was constructed by feeding ApoE−/− mice a high‐fat diet (R&D12108C) for 24 weeks.[31] The experiment was divided into normal diet (ND), high‐fat diet (HFD), and HFD plus SHep‐EV (75 μg of SHep‐EV were injected weekly via the tail vein for a total of 24 weeks) groups.