EVs derived from steatotic hepatocytes have been observed to promote atherosclerosis by inducing endothelial inflammation.[19] Analyses of murine plasma inflammatory factors revealed that levels of the inflammatory factor IL‐1β were significantly increased in the SHep‐EVs group, but remained unclear as to whether SHep‐EVs can promote macrophage proliferation and phenotypic transformation. Here, IL1B is linked to atherosclerosis.