LGALS3 and atherosclerosis: In addition, previous studies have shown that Lgals3bp is up‐regulated in patients with MAFLD.[53] More importantly, Lgals3bp can promote the osteogenic differentiation of stem cells by binding to Lgals3.[42] This evidence suggests that Lgals3bp may be an important mediator through which SHep‐EVs can promote atherosclerosis and calcification.