In the former report, the siblings, a boy and a girl, who were also homozygous for the RTTN c.2953A>G variant, were not formally diagnosed with TALS but they presented all the typical features of it: severe growth retardation, severe microcephaly (with lissencephaly), eczema and developmental delay. The gene discussed is RTTN; the disease is Eczematoid dermatitis.