The Taybi-Linder syndrome (TALS), or MOPD1 (OMIM #210710), is a very rare genetic disease with less than 100 reported cases [1–6] characterized by severe pre- and post-natal growth delay, severe microcephaly with brain abnormalities (abnormal gyral pattern, intracranial cyst, cerebellar vermis hypoplasia and corpus callosum agenesis), intellectual deficiency, bone abnormalities, bulging eyes and dry skin with eczema, as well as a premature death during the first months of life for the most severe cases [7–9]. The gene discussed is RNU4ATAC; the disease is microcephaly.