Potential biological and psychological pathways in support of these theories have been demonstrated: a dose-response relationship (i.e., accumulation) between cumulative trauma in childhood and inflammatory biomarkers (e.g., C-reactive protein) in middle-aged UK cohorts [29,69], and more widely with mental health issues, especially PTSD among older populations [19,70]. The gene discussed is CRP; the disease is post-traumatic stress disorder.