Besides their relevance in basic knowledge about myelination, as modulated by membrane lipid‐content, some of these mice are also established disease models for human demyelinating diseases and key tools for testing novel therapeutical strategies.[78, 99] Likewise, with this work, Beclin 1 emerges with a major role in SC homeostasis and as a candidate target in the modulation of PI3P‐associated signals, typically altered in demyelinating neuropathies. Here, BECN1 is linked to demyelinating disease.