UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: UMOD mutations cause monoallelic autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD, OMIM #16200), a non-proteinuric disorder with decreased fractional excretion of urate, early-onset gout, and a variable onset and gradual decline in kidney function leading to failure at approximately 54 years (11, 12).