To investigate the mechanism underlying the Evi1-OE–mediated development of MDS/MPN–like disease, we performed global gene expression profiling of a stem cell–enriched population (LSKs) isolated from the recipients that received BM cells from Mx1-Cre Tg (LSL-Evi1) or Tg (LSL-Evi1) mice 4 weeks after poly(I:C) injection. This evidence concerns the gene RUNX1 and myeloproliferative disorder.