Together, these findings suggest that Evi1-overexpressing myeloid progenitor cells gained a growth/repopulation advantage over the WT HSPCs, promoting clonal dominance of Evi1hi myeloid progenitor cells in vivo in mice, recapitulating the process of MDS/MPN development observed in patients. The gene discussed is RUNX1; the disease is myeloproliferative neoplasm.