To explore the potential contribution of the BM microenvironment to Evi1-induced MDS/MPN disease in mice, we transplanted BM cells from Evi1-OE or WT mice (CD45.2+) into lethally irradiated WT synergetic recipient mice (CD45.1+) (Supplemental Figure 3A). Here, RUNX1 is linked to myelodysplastic syndrome.