The penetrance of severe LAV and naturally acquired viral diseases seems to be incomplete, as previously seen in patients with AR complete IFNAR1 or IFNAR2 deficiency, whereas penetrance is higher for infections with certain viruses, such as SARS-CoV-2 than for HSV-1 (Hernandez et al., 2019; Bastard et al., 2021b, 2021c, 2022a; Zhang et al., 2020, 2022b; Duncan et al., 2015, 2022; Passarelli et al., 2020). The gene discussed is IFNAR2; the disease is infection.