Moreover, this situation is different from that for other AD inborn errors of immunity operating by negative dominance, such as AD deficiencies of IFNGR1 and IL6ST, for which negative dominance results from an accumulation at the cell surface of the LOF protein due to a deletion of the cytoplasmic recycling motif (Jouanguy et al., 1999; Béziat et al., 2020). Here, IFNGR1 is linked to Alzheimer disease.