The penetrance of severe LAV and naturally acquired viral diseases seems to be incomplete, as previously seen in patients with AR complete IFNAR1 or IFNAR2 deficiency, whereas penetrance is higher for infections with certain viruses, such as SARS-CoV-2 than for HSV-1 (Hernandez et al., 2019; Bastard et al., 2021b, 2021c, 2022a; Zhang et al., 2020, 2022b; Duncan et al., 2015, 2022; Passarelli et al., 2020). This evidence concerns the gene IFNAR2 and viral infectious disease.