IFNAR1 and herpes simplex encephalitis: Herpes simplex virus 1 (HSV-1) encephalitis (HSE) has been reported in a patient with a distinctive form of AR complete IFNAR1 deficiency in which a non-functional IFNAR1 is expressed on the cell surface at levels similar to those typically observed for the wildtype IFNAR1 (Bastard et al., 2021b).