The fact that de novo expression of PLAP was linked to features of aggressive disease in colorectal cancer in our previous IHC analysis of 652 cancers [10] and that RNA data from database suggested a poor prognosis of PLAP expressing lung, pancreatic, and colorectal cancers (data available from https://www.proteinatlas.org/ENSG00000163283-ALPP/pathology [26]) would be consistent with a functional role of PLAP in cancer cells. This evidence concerns the gene ALPP and cancer.