CAV1 and colonic neoplasm: However, high expression of Cav-1 in CAFs in the stroma also brings about pro-invasive effects and high expression of Cav-1 has been found in breast and colon cancers, where it has been found to regulate Rho-mediated cellular contraction through p190-dependent regulation leading to structural disorganization of the ECM, and enhancement of peripheral cell migration [148].