Finally, TNFα-induced protein 8-like protein 1 (TIPE1) inhibits osteosarcoma carcinogenesis and metastatic activity by binding to and inhibiting PRMT1 which is required for the asymmetric dimethylation of STAT3 on R688 (STAT3R688me2a), a modification that stimulates the activity of STAT3 itself [92]. The gene discussed is STAT3; the disease is osteosarcoma.