Infection of THP‐1‐derived macrophage by SARS‐CoV‐2 has been shown to activate NLRP3 inflammasome.[21] To further assess whether HMSA‐06 could also hamper the NLRP3‐mediated inflammatory response induced by SARS‐CoV‐2, we used a THP‐1 stably expressing ACE2 cell model (THP‐1‐ACE2). This evidence concerns the gene ACE2 and infection.