NLRP3 and COVID-19: NLRP3‐mediated inflammation reaction drives COVID‐19 pathology, as demonstrated in different cell and animal models.[21, 22, 28] NLRP3 inflammasome activation in microglia cells has also been linked to the neurological manifestation in COVID‐19 patients.[40] Despite several SARS‐CoV‐2 proteins or viral replication having been implicated in inducing the NLRP3 inflammasome activation, the detailed mechanisms are not fully understood.