DNA methylation, a key epigenetic mechanism regulating gene expression, is catalyzed by DNMTs, enzymes that convert cytosine to 5‐mC.[3] In cancer biology, research has highlighted the central role of epigenetic dysregulation in carcinogenesis, positioning epigenetic modifications as promising therapeutic targets.[5a] While DNMT inhibitors have been explored as potential anticancer treatments,[5a] our study reveals an alternative perspective: chemotherapy‐induced DNA hypomethylation and the downregulation of DNMT3a expression. Here, DNMT3A is linked to cancer.